The Regis College Police Department is operational 24 hours a day, 365 days a year. Officers are fully trained first responders and receive police powers through the Massachusetts State Police. The Regis College Police Department consists of a Chief, Deputy Chief, four Sergeants, Patrol Officers, Community Service Officers (CSO) and Dispatchers.

Working with the Office of the Dean of Students, the Regis College Police Department runs several safety awareness and crime prevention programs throughout the school year.

The Regis College Police Department maintains a close working relationship with Weston Police and Fire Departments, as well as state and federal law enforcement authorities. Informational meetings are held on a regular basis with the Weston Police Department to gather data on incidents occurring in Weston or the surrounding towns that may effect Regis.