Regis is committed to ensuring a healthy and safe environment for all community members to live, study and work.

The university's campus is staffed by highly trained and professional first responders who are experienced in handling all scenarios including active shooter situations, sexual assaults, fires and critical health emergencies. Staff who live on campus specialize in crisis and victim response. Additionally, the university utilizes Ethics Point, a third-party system that allows members of the Regis community to file formal complaints anonymously.

The Regis College Police Department is operational 24 hours a day, 365 days a year. Officers receive full police powers through the Massachusetts State Police. The campus police force consists of a chief, deputy chief, lieutenant, and two sergeants.