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The Corporation was established by the Congregation of the Sisters of St. Joseph of Boston in 1927. The Corporation has the power to elect Trustees and officers of the Board as well as amend the by-laws of the university.
- Mary L. Murphy, CSJ, MEd – President
- Marian Batho, CSJ, '70, MS – Secretary
- Kevin Conroy, JD – Treasurer
- John M. Gray, MBA, JD – Chair of the Board of Trustees
- Antoinette Hays, PhD, RN – President of Regis College
- Rosemary Brennan, CSJ, '70, MEd, MDiv
- Leila A. (Lee) Hogan, CSJ, '61, PhD
- Jacquelyn McCarthy, CSJ, MA, RN
- Kathleen McCluskey, CSJ, PhD
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