Brian Plouffe

Assistant Professor

Watson-Hubbard Science Center 303
Department STEM

Mailing Address

Regis College

235 Wellesley Street
Weston, MA 02493


Dr. Plouffe is currently the Founder and Undergraduate Director of the Biomedical Engineering program at Regis College. He teaches Biomedical Engineering courses, as well as Chemistry courses within the STEM department. Prior to joining Regis College in 2015, Dr. Plouffe was an adjunct professor at Northeastern University in the Chemical Engineering and Bioengineering departments; and a post-doctoral research associate in the lab of Dr. Shashi Murthy, where he investigated novel testing platforms for road-side THC detection. In addition, to his teaching and research at Northeastern, he co-founded the Chemical Engineering Writing Center to assist graduate students and post-doctoral researchers work on their writing of research articles, grants, posters, and presentation. Dr. Plouffe currently serves on the Education Committee of the Biomedical Engineering Society and is a member of the American Society for Engineering Education. Finally, Dr. Plouffe is the co-founder of Quad Technologies (Woburn, MA), a start-up focused on developing best-in-class cell separation reagents for immuno-oncology and translational medicine applications.


Dr. Plouffe’s research focuses on developing new point-of-care diagnostic and therapeutic monitoring platforms. Specifically, he develops microfluidic platforms that allow for the precise manipulation and selective separation of key cell populations from blood and tissue biopsy samplings. Recent research has expanded this work into proteomic analysis of rare cell populations; work has also extended to assays for illicit drug use while driving roadside – similar to current breathalyzers for alcohol.

Dr. Plouffe also has research interest in understanding the transition of high school students into college, with a focus on first-generation and minority students’ preparation for the STEM disciplines. A major challenge facing students as they pursue a postsecondary degree is a lack of academic preparedness for college-level coursework, and, in particular, college-level math. Entering college underprepared for the math curriculum required in many STEM degrees has a profound influence on student interest in science and engineering, therefore new pedagogical approaches are need to draw and retain students in these majors and improve students overall success in college.


Post-Doctoral, Northeastern University, 2012 – 2015

Post-Doctoral, Massachusetts Institute of Technology, 2011 – 2012

PhD, Chemical Engineering, Northeastern University, 2011

MS, Chemical Engineering, Northeastern University, 2007

BS, Chemical Engineering, University of Rhode Island, 2004

Awards Honors

Davis Educational Foundation, 2016

Virginia Pyne Kaneb Faculty Scholars, 2016 - 2017

Richard Saferstein Postdoctoral Fellowship, 2012 – 2015

National Science Foundation and National Cancer Institute IGERT Nanomedicine Science and Technology Doctoral Fellowship, 2008 – 2011

Elected to Tau Beta Pi Engineering Honor Society (RI-β), 2003

B.D. Plouffe and S.K. Murthy. “Fluorescence-based Lateral Flow Assays for Rapid Oral Fluid Roadside Detection of Cannabis Use” Electrophoresis 38: 501-506 (2017)

S. Li, B.D. Plouffe, A.M. Belov, S. Ray, X. Wang, S.K. Murthy, B.L. Karger, and A.R. Ivanov. “An Integrated Platform for Isolation, Processing and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood” Molecular and Cellular Proteomics 14: 1672–1683 (2015)

B.D. Plouffe, S.K. Murthy, and L.H. Lewis. “Fundamentals and Application of Magnetic Particles in Biological Cell Separation” Reports on Progress in Physics 78: 016601 (2015) (Invited Review).

B.D. Plouffe and S.K. Murthy. “Perspective on Microfluidic Cell Separation: A Solved Problem?” Analytical Chemistry 86: 11481–11488 (2014) (Invited Perspectives Article).

B.D. Plouffe, M. Mahalanabis, L.H. Lewis, C.M. Klapperich, and S.K. Murthy. “Clinically Relevant Microfluidic Magnetophoretic Isolation of Rare-Cell Populations for Diagnostic and Therapeutic Monitoring Applications” Analytical Chemistry 84: 1336–1344 (2012).

Book Chapters

B. Zhu, B.D. Plouffe, and S.K. Murthy, “Functionalized Microfluidic Devices for Separation of Cell Phenotypes,” in Microfluidic Cell Culture Systems, C.J. Bettinger, J.T. Borenstein, and S.L. Tao, Editors; Elsevier Publishing: 2013.

R.K. Iyer, B. Plouffe, S.K. Murthy, and M. Radisic. “Microreactors for Cardiac Tissue Engineering,” in Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications, A. Khademhosseini, J. Borenstein, S. Takayama, and M. Toner, Editors; Artech House Publishing: 2008.

Patent Applications

B.D. Plouffe, S.H. Kevlahan, and J. Zonderman. “Shaped Articles Including Hydrogels And Methods Of Manufacture And Use Thereof” International Application No. PCT/ US2015/148512; filed March 24, 2014. Assignee: QT Holding Corp (d/b/a Quad Technologies)

S.H. Kevlahan and B.D. Plouffe. “Methods and Composition for Highly Specific Biomolecule Separation and Purification” Provisional U.S. Patent Application No. 61/761,420; filed February 6, 2013. Assignee: Northeastern University (Licensed to Quad Technologies)

S.K. Murthy, L.H. Lewis, and B.D. Plouffe. “Methods and Compositions for Magnetophoretic Separation of Biological Materials,” International Application No. PCT/US2012/23864; filed February 3, 2012. Assignee: Northeastern University.