This course explores the principles and methods of radiation protection, health physics units, measurement, and dose-limiting regulations for occupationally and non-occupationally exposed individuals; radiation surveys; techniques and decontamination methods; monitoring of radioactive waste, radiation dose measurements, and radionuclide accountability; and special topics, including precautions with brachytherapy patients, with patients receiving therapeutic amounts of radionuclides and in management of accidentally contaminated individuals. This course will also serve as an overview of the genetic and somatic effects of ionizing radiation. Mechanisms of interaction from the subcellular level to the organism will be presented. Risk versus benefit of radiation exposure to occupational workers as well as patients will be discussed. The emphasis of the course will be an understanding of the theory of radiobiology and how this translates into radiation protection practices.