Neuroscience

Steven Threlkeld

Associate Professor and Program Director of Neuroscience

e steven.threlkeld@regiscollege.edu
t 781-768-7598

Education

PhD, Behavioral Neuroscience, University of Connecticut, 2008

MA, Behavioral Neuroscience, University of Connecticut, 2006

BA, Psychology, University of Portland, 2003

Experience

Prior to joining Regis College in 2016, Dr. Threlkeld was an associate and assistant professor at Rhode Island College and coordinator for the Behavioral Neuroscience program; and a research associate in pediatrics in the Perinatal Brain Research Laboratory at Women & Infants Hospital and the Warren Alpert Medical School of Brown University, where he studied blood brain barrier dysfunction associated with neonatal brain injury. He was also a teaching assistant at the University of Connecticut in Storrs, CT and has served as an adjunct assistant professor of Pediatrics at Women and Infants Hospital in collaboration on NIH-funded projects, in addition to consulting for the Blood Brain Barriers lab in the Department of Emergency Medicine at Rohde Island Hospital in Providence, RI. He is a member of the Society for Neuroscience and Faculty for Undergraduate Neuroscience. 

Publications

Gaudet C.M*., Lim Y.P., Stonestreet B.S., Threlkeld S.W. (2016). Effects of Age, Experience and Inter-alpha Inhibitor Proteins on Working Memory and Neuronal Plasticity after Neonatal Hypoxia-Ischemia. Behav. Brain Res. 302: 88-99.

Chen X., Sadowska G.B., Zhang J., Kim J.E., Cummings E.E., Bodge C.A., Lim Y.P., Makeyev O., Besio W.G., Gaitanis J., Threlkeld S.W., Banks W.A., Stonestreet B.S. (2015). Neutralizing anti-interleukin-1beta antibodies modulate fetal blood-brain barrior function after ischemia. Neurobiol Dis. 73:118-29.

Threlkeld S.W., Gaudet C.M*., LaRue M.E*., Dugas E*., Hill C.A., Lim Y.P., Stonestreet B.S. (2014). Effects of inter-alpha inhibitor proteins on neonatal brain injury: age, task and treatment dependent neurobehavioral outcomes. Experimental Neurology, 261C:424-433.

Spasova M.S., Sadowska G.B., Threlkeld S.W., Lim Y.P., Stonestreet B.S. (2014). Ontogeny of inter-alpha inhibitor proteins in ovine brain and somatic tissues. Experimental Biology and Medicine, 239(6):724-736.

Fitch R.H., Alexander M., Threlkeld S.W. (2013). Early neural disruption and auditory processing outcomes in rodent models: Implications for developmental language disability. Special Issue: What we learn and when we learn it: sensitive periods in development. Frontiers in Systems Neuroscience, 7:58.

Penley S.C., Gaudet C.M*., Threlkeld S.W. (2013). Use of an eight-arm radial water maze to assess working and reference memory following neonatal brain injury. Journal of Visualized Experiments, 82:50940.

Szalkowski C.E., Booker A.B., Truong D.T., Threlkeld S.W., Rosen G.D., Fitch R.H. (2013). Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy. Developmental Neuroscience. 35(1):50-68.

Threlkeld S.W., Hill C.A., Szalkowski C.E., Truong D.T., Rosen G.D., Fitch R.H. (2012). Effects of test experience and neocortical microgyria on spatial and non-spatial learning in rats. Behavioral Brain Research. 235(2): 135-5.

Chen X., Threlkeld S.W., Cummings E.E., Juan I., Makeyev O., Besio W.G., Gaitanis J., Banks W.A., Sadowska G.B., Stonestreet B.S. (2012). Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus. Neuroscience. 226C: 89-100.

Chen X., Threlkeld S.W., Cummings E.E., Sadowska G.B., Lim Y.P., Padbury J.F., Sharma S., Stonestreet B.S. (2012). In-vitro validation of cytokine neutralizing antibodies by testing with ovine mononuclear splenocytes. Journal of Comparative Pathology. 148(2-3): 252-8.

Sadowska G.B., Threlkeld S.W., Flangini A., Sharma S., Stonestreet B.S. (2012). Ontogeny and the effects of in-utero brain ischemia on interleukin-1beta and interleukin-6 protein expression in ovine cerebral cortex and white matter. International Journal of Developmental Neuroscience. 30(6): 457-63.

Hill C.A., Threlkeld S.W., Rosen G.D., Fitch R.H. (2011). Early testosterone modulated sex differences in behavioral outcome following neonatal hypoxia-ischemia in rats. International Journal of Developmental Neuroscience. 29(6): 621-8.

Szalkowski C.E., Hinman J.R., Threlkeld S.W., Wang Y., Rosen G.D., Chrobak J.J., Fitch R.H. (2011). Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1. Genes Brain and Behavior. 10(2): 244-52.

Threlkeld S.W., Lynch J.L., Lynch K.M., Sadowska G., Stonstreet B.S., Banks W.A., (2010). Ovine pro-inflammatory cytokines cross the murine blood brain barrier by a common saturable transport mechanism. Neuroimmunomodulation, 17(6):405-410.

Threlkeld, S.W., Hill, C.A., Cleary, C., Troung, D., Rosen, G.D., Fitch, R.H., (2009).  Developmental learning impairments in a rodent model of nodular heterotopia. J Neurodev Disord. 1(3): 237-250.

Threlkeld, S.W., Hill, C.A., Rosen, G.D., Fitch, R.H., (2009).  Early acoustic discrimination experience ameliorates auditory processing deficits in male rats with cortical developmental disruption.  Int J Dev Neurosci, 27(4), 321-328.

Threlkeld, S.W., Penley, S.C., Rosen, G.D., Fitch, R.H., (2008). Detection of silent gaps in white noise following cortical deactivation in rats. Neuroreport, 19 (8): 893-8.

Fitch R.H., Threlkeld, S.W., McClure, M.M., Peiffer, A.M., (2008). Use of a modified prepulse inhibition paradigm to assess complex auditory discrimination in rodents. Brain Res Bull, 76 (1-2): 1-7.

Threlkeld, S.W., Rosen, G.D., Fitch, R.H., (2007). Age at developmental cortical injury differentially alters corpus callosum volume in the rat. BMC Neuroscience, 12; 8: 94.

Threlkeld, S.W., McClure, M. M., Bai, J., Wang, Y., LoTurco, J.J., Rosen, G.D., & Fitch, R. H., (2007). Developmental Disruptions and Behavioral Impairments in Rats Following In Utero RNAi of Dyx1c1. Brain Res Bull, 71(5): 508-14.

Rosen, G.D., Bai, J., Wang, Y., Fiondella, C.G., Threlkeld, S.W., Loturco, J.J., Galaburda, A.M., (2007). Disruption of neuronal migration by RNAi of Dyx1c1 results in neocortical and hippocampal malformations. Cereb Cortex, 17(11): 2562-72.

McClure, M.M., Threlkeld, S. W., & Fitch, R. H., (2007). Auditory processing and learning/memory following erythropoietin administration in neonatally hypoxic-ischemic injured rats. Brain Res, 1132(1): 203-9.

Threlkeld, S.W., McClure, M.M., Rosen, G.D., Fitch, R.H., (2006). Developmental Timeframes for Induction of Microgyria and Rapid Auditory Processing Deficits in the Rat. Brain Res, 1109(1): 203-9.

McClure, M. M., Threlkeld, S. W., Rosen, G. D., & Fitch, R. H., (2006). Rapid auditory processing and learning deficits in Rats with P1 versus P7 neonatal hypoxic-ischemic injury. Behav Brain Res, 172(1): 114-21.

McClure, M. M., Threlkeld, S. W., & Fitch, R. H., (2006). The Effects of Erythropoietin on Auditory Processing Following Neonatal Hypoxic-Ischemic Injury. Brain Res, 1087(1): 190-5.

McClure, M. M., Threlkeld, S. W., Rosen, G. D., & Fitch, R. H., (2005). Auditory processing deficits in unilaterally and bilaterally injured hypoxic-ischemic rats. Neuroreport, 16: 1309-1312.

Peiffer, A. M., McClure, M. M., Threlkeld, S. W., Rosen, G. D., & Fitch, R. H., (2004). Severity of focal microgyria and associated rapid auditory processing deficits. Neuroreport, 15: 1923-1926.

Presentations

Psychology Department Brown Bag, Rhode Island College, Providence, RI, March 16th, 2016. Experimental approaches for promoting neuronal plasticity and behavioral recovery after brain injury.

Psychology Research Colloquium, Villanova University, Villanova, PA, April 20th 2015. Protection and Plasticity in Neonatal Brain Injury: Insights into Recovery of Function Following Immunotherapy and Behavioral Training.

Pediatric Research Colloquium, Women and Infants Hospital, Brown medical school, Providence, RI, January 9th 2015, Providence RI, Combining intervention strategies improves high demand working-memory performance in rats with neonatal brain injury.

Molecular Pharmacology, Physiology & Biotechnology Colloquium, Brown University, Providence, RI, May 23rd 2014. Effects of inter-alpha inhibitor proteins on neonatal brain injury: age, task and treatment dependent neurobehavioral outcomes.

Grantrepreneurship: School of Management Faculty Development workshop. Rhode Island College, Providence, RI, January 16, 2014. Successful grant writing at primarily undergraduate institutions.

Eliminating Boundaries with H.O.P.E. (Helping Others Promote Equality) conference, Rhode Island College, Providence, RI, March 22nd 2013. Understanding the causes and influences of sexual orientation and gender: A review of what is known.

Neuroscience Research Colloquium, Western New England University, Springfield MA, November 13th, 2012. Neurobehavioral remediation following inter-alpha-inhibitor protein treatment in a model of neonatal brain injury.

Pediatric Research Colloquium, Women and Infants Hospital, Brown medical school, Providence, RI, November 2nd, 2012. Neurobehavioral remediation following inter-alpha-inhibitor protein treatment in a model of neonatal brain injury.

Diversity Week Seminar, Rhode Island College, Providence, RI, October, 2012. Teaching strategies for a diverse student population. Co-presenter with Keri Rossi-D’enteremont

Biology Colloquium Series, Rhode Island College, Providence, RI, September 27th, 2012. Novel neurobehavioral protection following inter-alpha-inhibitor protein treatment in a model of perinatal brain injury.

Psychology Colloquium Series, Roger Williams University, April 2012, Bristol, Rhode Island, Title: Insight into human developmental learning impairments from rodent models of early neuropathology.

Pediatric Research Colloquium, Women and Infants Hospital, Brown medical school, Providence, RI, February 2009, Providence RI, Title: Maturation and experience-dependent improvements in auditory processing for rats with neocortical developmental disruption.

Pediatric Research Colloquium, Women and Infants Hospital, Brown medical school, June 2008, Providence, RI, Title: Overlap and Insight from Genetic and Teratogenic Models of Developmental Learning Impairment in the Rat.

International Society for Behavioral Neuroscience, July 2006, Bath Spa University, Bath, UK, Title: Behavioral Impairments Following In Utero RNAi of Dyx1c1 in the Rat

Research

Dr. Threlkeld’s research focuses on understanding the anatomical, behavioral and auditory sensory consequences of neonatal hypoxia-ischemia and developmental brain malformations (associated with premature birth and infection in humans) and potential behavioral and pharmacological intervention strategies using rodent models. Recent research has expanded this work into investigations of novel peptide-based therapeutics on anatomical and behavioral consequences of adult traumatic brain injury with the application of novel approaches to study behavioral and sensory outcomes in pre-clinical models.

Awards

Neuroprotection in TBI with a new multifunctional peptide-based therapeutic. NIH RO1, Form the National Institutes of Neurological Diseases and Stroke. $130,350.00 (five year total costs). 2017-20221. Co PIs: Marshall (Brown University) and Chodobski (Rhode Island Hospital). Co-Investigator (Sub-award Regis College): Threlkeld

Neonatal brain injury: Mediating factors for improved neurobehavioral outcome. NIH R15HD077544, from the Eunice Kennedy Shriver National Institutes of Child Health and Human Development. $329,762.00 (three year total costs). 2013-2017. Principle Investigator: Threlkeld

Anti-inflammatory intervention and neurobehavioral outcome in neonatal ischemia. RI-INBRE Award # P20RR016457-11 from the NIH, National Center for Research Resources (NCRR). $267,690.00 (two year total costs). 2011-2013. Principle Investigator: Threlkeld

University of Connecticut, Graduate School Doctoral Dissertation Fellowship, 2008 ($2,000)

University of Connecticut, Neuroscience Fellowship, 2007 ($1,000), 2008 ($1,000)

University of Connecticut, Behavioral Neuroscience Zarrow award, 2003 ($1,500)

Neuroscience Department


t 781-768-7598
e steven.threlkeld@regiscollege.edu

Mailing Address


Regis College
Science Building 104
235 Wellesley Street
Weston, MA 02493
PO Box 10
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